Article : First Documented Case of Child Cured of HIV

First Documented Case of Child Cured of HIV

Mar. 3, 2013 — Dr. Deborah Persaud of Johns Hopkins University today described the first documented case of a child being cured of HIV. The landmark findings were announced at the 2013 Conference on Retroviruses and Opportunistic Infections in Atlanta, GA.

Dr. Persaud, an amfAR grantee, detailed the case of a two-year-old child in Mississippi diagnosed with HIV at birth and immediately put on antiretroviral therapy. At 18 months, the child ceased taking antiretrovirals and was lost to follow-up. When brought back into care at 23 months, despite being off treatment for five months, the child was found to have an undetectable viral load. A battery of subsequent highly sensitive tests confirmed the absence of HIV.

Confirmation of the cure was made possible by a grant the Foundation awarded to Dr. Persaud and Dr. Katherine Luzuriaga of the University of Massachusetts in September 2012. The grant allowed Drs. Persaud and Luzuriaga to establish a research collaboratory to explore and document possible pediatric HIV cure cases. The collaboratory includes renowned researchers Drs. Stephen Spector and Doug Richman at the University of California, San Diego; Dr. Frank Maldarelli at the National Cancer Institute; and Dr. Tae-Wook Chun at the National Institute of Allergy and Infectious Diseases.

"The child's pediatrician in Mississippi [Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi] was aware of the work we were doing, and quickly notified our team as soon as this young patient's case came to her attention," said Dr. Rowena Johnston, amfAR vice president and director of research. "Because the collaboratory was already in place, the researchers were able to mobilize immediately and perform the tests necessary to determine if this was in fact a case of a child being cured."

According to Dr. Persaud, comprehensive tests have confirmed beyond doubt that both mother and child were HIV positive when the child was born, and today no signs of HIV infection in the child can be detected by the most sensitive means available.

The only other documented case of an HIV cure to date remains that of Timothy Brown, the so-called "Berlin patient." In 2006, while on treatment for HIV, Mr. Brown was diagnosed with leukemia. His physician was able to treat his leukemia with a stem-cell transplant from a person who was born with a genetic mutation causing immunity to HIV infection. Following the transplant, Mr. Brown was able to stop HIV treatment without experiencing a return of his HIV disease.

This new case points to the tantalizing possibility that different populations of HIV-positive people might be cured in different ways. While Mr. Brown's case was the outcome of a complex, high-risk, and expensive series of procedures, this new case appears to have been the direct result of a comparatively inexpensive course of antiretroviral therapy.

"Given that this cure appears to have been achieved by antiretroviral therapy alone," said Dr. Johnston, "it is also imperative that we learn more about a newborn's immune system, how it differs from an adult's, and what factors made it possible for the child to be cured."

The Mississippi case also underscores the importance of identifying HIV-positive pregnant women, expanding access to treatment regimens than can prevent mother-to-child transmission, and of immediately putting infants on antiretroviral therapy in the event that they are born HIV positive.

"We are proud to have played a leading role in bringing this first pediatric HIV cure to light," said amfAR CEO Kevin Robert Frost. "The case is a startling reminder that a cure for HIV could come in ways we never anticipated, and we hope this is the first of many children cured of HIV in the months and years to come."

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Voilà vraiment une nouvelle fabuleuse

Oui.Peut-être le début de la fin d'un immense tunnel

Je viens d'entendre à la radio qu'il ne s'agissait pas d'une guérison mais d'une non-reprise du virus (la patiente demeure infectée). Cela demeure une super nouvelle quand même! (par contre les parents n'ont pas ramené l'enfant pendant plusieurs mois à l'hôpital alors qu'ils la savaient malade?)

Marcel Khrouchtchev a écrit:Voilà vraiment une nouvelle fabuleuse

Oui, une nouvelle très longtemps attendue.

Heu, les gars, vous qui faites des stats, c'est un cas, il n'y a pas d'étude clinique, le suivi était défaillant, il n'y a pas de recul, ce n'est pas forcément élargissable aux adultes, donc faut pas s'emballer non plus (je ne veux pas jouer les rabat-joie mais avec tous les enfants qui sont morts ou mourants à cause de cette saleté, il faut rester prudent non?)

dandelion a écrit:Heu, les gars, vous qui faites des stats, c'est un cas, il n'y a pas d'étude clinique, le suivi était défaillant, il n'y a pas de recul, ce n'est pas forcément élargissable aux adultes, donc faut pas s'emballer non plus (je ne veux pas jouer les rabat-joie mais avec tous les enfants qui sont morts ou mourants à cause de cette saleté, il faut rester prudent non?)

C'est surtout que ça va dans le bon sens. Mes copains séropos ont quasiment divisé leur traitement de fond par 8 ou 10 en 20 ans, disons qu'ici ou là apparaissent de petits signes encourageants, si l'on excepte bien sûr cette stupide "mode" du relapse. Faut dire que ça pouvait difficilement empirer depuis trente ans